Cyclooxygenase-2 (COX-2) polymorphism rs689466 may contribute to the increased susceptibility to post-traumatic osteomyelitis in Chinese population

Abstract

Background: Cyclooxygenase-2 (COX-2) enzyme is one of the major mediators during inflammation reactions, and COX-2 gene polymorphisms of rs20417 and rs689466 have been reported to be associated with several inflammatory diseases. However, potential links between the two polymorphisms and risk of developing post-traumatic osteomyelitis remain unclear. The present study aimed to investigate associations between the rs20417 and rs689466 polymorphisms and susceptibility to post-traumatic osteomyelitis in Chinese population.

Methods: A total of 189 patients with definite diagnosis of post-traumatic osteomyelitis and 220 healthy controls were genotyped for rs20417 and rs689466 using the SNaPshot genotyping method. Chi-square test was used to compare differences of genotype distributions as well as outcomes of five different genetic models between the two groups.

Results: Significant association was found between rs689466 and post-traumatic osteomyelitis by recessive model (GG vs. AA + AG) (OR = 1.74, 95% CI: 1.098–2.755, p = .018). Although no statistical differences were identified of rs689466 between the two groups by allele model (p = .098) or homozygous model (p = .084), outcomes revealed a tendency that allele G may be a risk factor and people of GG genotype may be in a higher risk to develop post-traumatic osteomyelitis in Chinese population. However, no significant link was found between rs20417 and susceptibility to post-traumatic osteomyelitis in this Chinese cohort.

Conclusions: To our knowledge, we reported for the first time that COX-2 gene polymorphism rs689466 may contribute to the increased susceptibility to post-traumatic osteomyelitis in Chinese population.

Keywords:

• Post-traumatic osteomyelitis
• single nucleotide polymorphism
• COX-2 gene
• rs20417
• rs689466
• case-control study

Acknowledgements

The authors thank Prof. Allen P. Liang for his contribution to revise this paper.

Disclosure statement

The authors declare that they have no conflict of interests.

Additional information

Funding

This study was supported by National Natural Science Foundation of China (Grant No. 81572165), Guangdong Provincial Science and Technology Department Plan Projects (Grant No. 2016B090913004), Guangzhou Science and Technology Program key projects Plan Projects (Grant No. 201508020035) and Presidential Foundation of Nanfang Hospital (Grant No.2014C014).