Combination of statins and hormone replacement therapy in postmenopausal women is associated with increased bone mineral density

V. De Leo Department of Pediatrics ,Obstetrics and Reproductive Medicine ,Institute of Obstetrics and Gynecology ,University of Siena ,Siena ,Italy

G. Morgante Department of Pediatrics ,Obstetrics and Reproductive Medicine ,Institute of Obstetrics and Gynecology ,University of Siena ,Siena ,Italy

A. la Marca Department of Pediatrics ,Obstetrics and Reproductive Medicine ,Institute of Obstetrics and Gynecology ,University of Siena ,Siena ,Italy

D. Lanzetta Department of Pediatrics ,Obstetrics and Reproductive Medicine ,Institute of Obstetrics and Gynecology ,University of Siena ,Siena ,Italy

L. Cobellis Department of Pediatrics ,Obstetrics and Reproductive Medicine ,Institute of Obstetrics and Gynecology ,University of Siena ,Siena ,Italy

F. Petraglia Department of Pediatrics ,Obstetrics and Reproductive Medicine ,Institute of Obstetrics and Gynecology ,University of Siena ,Siena ,Italy

Abstract

Recent studies have shown that statins might be potent inhibitors of bone resorption and osteoclast number ,and there is evidence for their bone anabolic effects. Statin treatment seems to protect against non-pathological fractures in older women. However ,contradictory findings have been obtained. In this retrospective study we found that postmenopausal women on statins and hormone replacement therapy (HRT) showed higher bone mineral density than women on HRT alone. This evidence provides further confirmation of the effect of statins on bone turnover and shows that the combination of HRT and statins reduces the risk of bone fracture by virtue of the antiresorptive effect of HRT and the anabolic and antiresorptive effects of statins.

Keywords

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Combination of statins and hormone replacement therapy in postmenopausal women is associated with increased bone mineral density

Information for

Open access

Opportunities

Help and information

Combination of statins and hormone replacement therapy in postmenopausal women is associated with increased bone mineral density

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature