Modification of the Action of Misonidazole Effect of TAN on Radiosensitization

K.A. Skov Medical Biophysics Unit, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B.C. V5Z IL3

B. Palcic Medical Biophysics Unit, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B.C. V5Z IL3

I.E. Harrison Medical Biophysics Unit, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B.C. V5Z IL3

L.D. Skarsgard Medical Biophysics Unit, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B.C. V5Z IL3

Abstract

Radiosensitization by misonidazole of hypoxic mammalian cells in dilute suspension is modified by the presence of the stable free radical, TAN. The dose modifying factor (DMF) of 15 mM misonidazole is 2·4 for cell inactivation, and 3·5 for the production of single-strand breaks in DNA. The presence of TAN decreases these values to 1·5 and 1·75 respectively. Possible explanations for these observations are discussed. The DMF of misonidazole for cells in pellet is not affected by TAN.

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Modification of the Action of Misonidazole Effect of TAN on Radiosensitization

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Modification of the Action of Misonidazole Effect of TAN on Radiosensitization

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