TREATMENT OF EXPERIMENTAL NEPHROSIS BY CULTURE FILTRATE OF CRYPTOCOCCUS NEOFORMANS VAR. GATTII (CneF)

Abbas Mirshafiey Department of Immunology, School of Public Health, Tehran University of Medical Sciences, P.O. Box 6446, Tehran, 14155, Iran

Alireza Razavi Department of Immunology, School of Public Health, Tehran University of Medical Sciences, P.O. Box 6446, Tehran, 14155, Iran

Farhad Mehrabian Department of Immunology, School of Public Health, Tehran University of Medical Sciences, P.O. Box 6446, Tehran, 14155, Iran

Mohammad R. Nikouei Moghaddam Department of Immunology, School of Public Health, Tehran University of Medical Sciences, P.O. Box 6446, Tehran, 14155, Iran

Masoumeh Hadjavi Department of Immunology, School of Public Health, Tehran University of Medical Sciences, P.O. Box 6446, Tehran, 14155, Iran

ABSTRACT

The therapeutic effect of the culture filtrate of cryptococcus neoformans var. gattii (CneF) was tested in Adriamycin-induced nephropathy. The CneF was administered at different doses (36, 54 and 90 mg/kg based on carbohydrate concentration), one i.p. injection every 72 hours for a total of 10 injections. The treated patient rats showed a significant reduction in proteinuria, plasma cholesterol concentration, BUN and significant increase in urine creatinine levels. Moreover, treatment with CneF significantly reduced number of glomerular leukocytes and decreased the tubular casts. These data suggest that CneF therapy can ameliorate proteinuria, hypercholesterolemia and suppress the progression of glomerular lesions in experimental model of nephrosis.

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TREATMENT OF EXPERIMENTAL NEPHROSIS BY CULTURE FILTRATE OF CRYPTOCOCCUS NEOFORMANS VAR. GATTII (CneF)

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TREATMENT OF EXPERIMENTAL NEPHROSIS BY CULTURE FILTRATE OF CRYPTOCOCCUS NEOFORMANS VAR. GATTII (CneF)

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