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ABSTRACT
A human hepatoma cell line, Hep G2 cell, is reliable for the study of alcohol-induced hepatotoxicity. In this study, we investigated the effect of an aqueous extract of Artemisia capillaris THUNB (Compositae) plant (AC) on ethanol (EtOH)-induced cytotoxicity in Hep G2 cells. AC (0.5–5 µg/mL) inhibited the secretion of EtOH-induced interluekin-1α (IL-1α) and tumor necrosis factor-α (TNF-α). AC also inhibited the EtOH-, IL-1α-, and TNF-α-induced cytotoxicity. Furthermore, we found that AC inhibited the EtOH-induced apoptosis of Hep G2 cells. These results suggest that AC may prevent the EtOH-induced cytotoxicity through inhibition of the apoptosis of Hep G2 cells.