EFFECT OF MYCOPHENOLATE MOFETIL ON THE PROGRESSION OF ADRIAMYCIN NEPHROPATHY

Abstract

In order to assess the effects of mycophenolate mofetil (MMF) on the development of adriamycin-induced nephropathy, the development of this nephropathy in rats treated with MMF was compared to that in non-treated animals (group ADR + V) over 28 weeks. At weeks 8, 16 and 20, 24-h proteinuria of the treated group statistically differed from that of the non-treated group. However, no significant difference in proteinuria was observed thereafter between the groups. At the end of the experiment, there was no significant difference between both groups regarding the frequency of glomerular lesion (Group ADR + V: Md = 35%, P25 = 20%, P75 = 68%; Group ADR + MMF: Md = 27%, P25 = 9.5%, P75 = 54%); tubulointerstitial lesion index (Group ADR + V: Md = 7, P25 = 1.5, P75 = 9; Group ADR + MMF: Md = 8, P25 = 2, P75 = 9); glomerulosclerosis area (group ADR + V = 2779 μm², P25 = 751.8 μm², P75 = 3115 μm²; Group ADR + MMF = 1147 μm², P25 = 3969.7 μm², P75 = 1560 μm²); and, interstitial fibrosis area (Group ADR + V: Md = 218200 μm², P25 = 78670 μm², P75 = 282700 μm² group ADR + MMF: Md = 136000, P25 = 25010, P75 = 255800 μm²). In conclusion, MMF caused a temporary reduction in proteinuria but did not change the severity of the renal lesion observed after 28 weeks.

• Adriamycin nephropathy
• Mycofenolate mofetil
• MMF
• Proteinuria
• Tubulointerstitial fibrosis
• Glomerulosclerosis