THE NEXT GENERATION OF LIPOSOME DELIVERY SYSTEMS: RECENT EXPERIENCE WITH TUMOR-TARGETED, STERICALLY-STABILIZED IMMUNOLIPOSOMES AND ACTIVE-LOADING GRADIENTS

R. M. Abra ALZA Corp., Mountain ViewCalifornia, 94025, U.S.A.

R. B. Bankert ALZA Corp., Mountain ViewCalifornia, 94025, U.S.A.

F. Chen Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, 14263, U.S.A.

N. K. Egilmez Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, 14263, U.S.A.

K. Huang ALZA Corp., Mountain ViewCalifornia, 94025, U.S.A.

R. Saville ALZA Corp., Mountain ViewCalifornia, 94025, U.S.A.

J. L. Slater ALZA Corp., Mountain ViewCalifornia, 94025, U.S.A.

M. Sugano Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, 14263, U.S.A.

S. J. Yokota Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, 14263, U.S.A.

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ABSTRACT

Three topics are discussed. Enhanced anti-tumor efficacy of targeted doxorubicin-containing sterically-stabilized liposomes using an anti-β₁ integrin Fab’ ligand. Use of tumor targeting with an internalizing ligand to improve the efficacy of a non-leaky cisplatin-containing sterically-stabilized liposome formulation. Formulation variables (remote-loading with dextran ammonium sulfate, rigid lipid bilayer) used to optimize in vivo performance of a liposomal camptothecin analog.

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THE NEXT GENERATION OF LIPOSOME DELIVERY SYSTEMS: RECENT EXPERIENCE WITH TUMOR-TARGETED, STERICALLY-STABILIZED IMMUNOLIPOSOMES AND ACTIVE-LOADING GRADIENTS

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THE NEXT GENERATION OF LIPOSOME DELIVERY SYSTEMS: RECENT EXPERIENCE WITH TUMOR-TARGETED, STERICALLY-STABILIZED IMMUNOLIPOSOMES AND ACTIVE-LOADING GRADIENTS

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