ISOTHERMIC TITRATION CALORIMETRY TO STUDY CMCs OF NEUTRAL SURFACTANTS AND OF THE LIPOSOME-FORMING BOLAAMPHIPHILE DEQUALINIUM®

ABSTRACT

Isothermic titration calorimetry was used to measure the heat of micelle formation (molar enthalpy of transfer of surfactants monomers from water into micellar aggregates. The problems associated with the estimation of the CMC and the whole therodynamic profile of micellization of surfactants via Gibbs-Helmholtz-Equation are discussed. CMC's of octylthioglucoside and the peculiar bolaamphilphile dequalinium® which concentrates in mitochondria are measured. In contrast to earlier reports, no CMC of dequalinium® could be found inspite of extensive systematic measurements.