LIPOSOME RECOGNITION BY RESIDENT AND NEWLY RECRUITED MURINE LIVER MACROPHAGES

ABSTRACT

The evidence in this communication indicate that, unlike resident Kupffer cells, newly recruited liver macrophages (following monocyte migration from the blood to the liver) use complement receptors to recognize and internalize stearylamine-incorporated liposomes. Within two weeks of hepatic residency complement receptors no longer participate in liposome recognition and uptake.

Keywords: :

• Blood monocytes
• Complement receptors
• Kupffer cells
• Diethylstilbestrol
• Mouse