OPTIMIZATION OF CATIONIC LIPID MEDIATED GENE TRANSFER: STRUCTURE-FUNCTION, PHYSICO-CHEMICAL, AND CELLULAR STUDIES

Marie Carrière Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire et Cellulaire, UMR 7001 CNRS ENSCP, Aventis ENSCP, 11 rue Pierre et Marie Curie, 75013 Paris and CRVA Aventis Pharma, 13 quai Jules Gesde B.P. 14, 94403Vitry sur Seine, France

Isabelle Tranchant Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire et Cellulaire, UMR 7001 CNRS ENSCP, Aventis ENSCP, 11 rue Pierre et Marie Curie, 75013 Paris and CRVA Aventis Pharma, 13 quai Jules Gesde B.P. 14, 94403Vitry sur Seine, France

Pierre-Antoine Niore Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire et Cellulaire, UMR 7001 CNRS ENSCP, Aventis ENSCP, 11 rue Pierre et Marie Curie, 75013 Paris and CRVA Aventis Pharma, 13 quai Jules Gesde B.P. 14, 94403Vitry sur Seine, France

Gerardo Byk Department of Chemistry, Laboratory of Peptidomimetics and Genetic Chemistry, Bar-Ilan University, Ramat Gan, 52900, Israel

Nathalie Mignet Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire et Cellulaire, UMR 7001 CNRS ENSCP, Aventis ENSCP, 11 rue Pierre et Marie Curie, 75013 Paris and CRVA Aventis Pharma, 13 quai Jules Gesde B.P. 14, 94403Vitry sur Seine, France

Virginie Escriou Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire et Cellulaire, UMR 7001 CNRS ENSCP, Aventis ENSCP, 11 rue Pierre et Marie Curie, 75013 Paris and CRVA Aventis Pharma, 13 quai Jules Gesde B.P. 14, 94403Vitry sur Seine, France

Daniel Scherman Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire et Cellulaire, UMR 7001 CNRS ENSCP, Aventis ENSCP, 11 rue Pierre et Marie Curie, 75013 Paris and CRVA Aventis Pharma, 13 quai Jules Gesde B.P. 14, 94403Vitry sur Seine, France

Jean Herscovici Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire et Cellulaire, UMR 7001 CNRS ENSCP, Aventis ENSCP, 11 rue Pierre et Marie Curie, 75013 Paris and CRVA Aventis Pharma, 13 quai Jules Gesde B.P. 14, 94403Vitry sur Seine, France

show all

ABSTRACT

The rationale design aimed at the enhancement of cationic lipid mediated gene transfer is discussed. These improvements are based on the straight evaluation of the structure-activity relationship and on the introduction of new structures. Much attention have been given to the supramolecular structures of the lipid/DNA complexes, to the effect of serum on gene transfer and to the intracellular trafficking of the lipoplexes. Finally new avenue using reducible cationic lipids has been discussed.

Keywords: :

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

OPTIMIZATION OF CATIONIC LIPID MEDIATED GENE TRANSFER: STRUCTURE-FUNCTION, PHYSICO-CHEMICAL, AND CELLULAR STUDIES

Information for

Open access

Opportunities

Help and information

OPTIMIZATION OF CATIONIC LIPID MEDIATED GENE TRANSFER: STRUCTURE-FUNCTION, PHYSICO-CHEMICAL, AND CELLULAR STUDIES

ABSTRACT

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature