LIGAND-TARGETED LIPOSOMES DIRECTED AGAINST PATHOLOGICAL VASCULATURE

Raymond M. Schiffelers Dept. of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), P.O. Box 80082, TB Utrecht, 3508, The Netherlands

Grietje Molema Dept. Pathology and Laboratory Medicine, Groningen University Institute for Drug Exploration (GUIDE), Groningen, The Netherlands

Timo L. M. ten Hagen Dept. of Surgical Oncology, Academic Hospital Rotterdam - Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

Adriënne P. C. A. Janssen Dept. of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), P.O. Box 80082, TB Utrecht, 3508, The Netherlands

Astrid J. Schraa Dept. Pathology and Laboratory Medicine, Groningen University Institute for Drug Exploration (GUIDE), Groningen, The Netherlands

Robbert J. Kok Dept. of Pharmacokinetics and Drug Delivery, GUIDE, Groningen, The Netherlands

Gerben A. Koning Dept. of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), P.O. Box 80082, TB Utrecht, 3508, The Netherlands

Gert Storm Dept. of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), P.O. Box 80082, TB Utrecht, 3508, The Netherlands

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ABSTRACT

The development of liposomes targeted to angiogenic endothelial cells offers exciting prospects for intervention in cancer and inflammation. Several proteins are (strongly) over-expressed on angiogenic endothelial cells as compared to the quiescent endothelium, and could potentially serve as targets for site-specific drug delivery. In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein.

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LIGAND-TARGETED LIPOSOMES DIRECTED AGAINST PATHOLOGICAL VASCULATURE

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