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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 31, 2001 - Issue 1
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Original Articles

SYNTHESIS OF 1-ARYLSULFONYL-3-N-(β-D-ACETYLGLYCOPYRANOS-1-YL)-5-FLUOROURACIL AND ANTITUMOR ACTIVITIES

Chang-Jun Sun Department of Chemistry, Shandong University, Jinan, 250100, P.R. China
,
Ji-Ming Zhang Department of Chemistry, Shandong University, Jinan, 250100, P.R. China
,
Shuang-Jia Wang Department of Chemistry, Shandong University, Jinan, 250100, P.R. China
,
Fen-Yan Zhou Department of Chemistry, Zaozhuang Normal College, Shandong, Zaozhuang, 277160, P.R. China
,
Yu-Xin Qi Department of Chemistry, Shandong University, Jinan, 250100, P.R. China
&
Min Lu Department of Chemistry, Shandong University, Jinan, 250100, P.R. China
Pages 71-75 | Received 02 Apr 2000, Published online: 09 Nov 2006
 
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Abstract

Fifteen glycosides of 1-arylsulfonyl-5-fluorouracil were synthesized by the reaction of 1-arylsulfonyl-5-fluorouracil with bromoacetylglucose or bromoacetylxylose under phase transfer catalysis. Their structures were confirmed by IR, 1HNMR, and elementary analysis. Preliminary results of in vitro tests showed that some of them have certain antitumor activities.

Acknowledgments

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