AN IMPROVED SYNTHESIS OF N-[(9-HYDROXYMETHYL)-2-FLUORENYL]SUCCINAMIC ACID (HMFS), A VERSATILE HANDLE FOR THE SOLID-PHASE SYNTHESIS OF BIOMOLECULES

Fernando Albericio Department of Organic Chemistry, University of Barcelona, Barcelona, 08028, Spain

Montse Cruz Department of Organic Chemistry, University of Barcelona, Barcelona, 08028, Spain

Laurent Debéthune Department of Organic Chemistry, University of Barcelona, Barcelona, 08028, Spain

Ramon Eritja Department of Organic Chemistry, University of Barcelona, Barcelona, 08028, Spain

Ernest Giralt Department of Organic Chemistry, University of Barcelona, Barcelona, 08028, Spain

Anna Grandas Department of Organic Chemistry, University of Barcelona, Barcelona, 08028, Spain

Vicente Marchán Department of Organic Chemistry, University of Barcelona, Barcelona, 08028, Spain

Jose J. Pastor Department of Organic Chemistry, University of Barcelona, Barcelona, 08028, Spain

Enrique Pedroso Department of Organic Chemistry, University of Barcelona, Barcelona, 08028, Spain

Francesc Rabanal Department of Organic Chemistry, University of Barcelona, Barcelona, 08028, Spain

Miriam Royo Department of Organic Chemistry, University of Barcelona, Barcelona, 08028, Spain

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Abstract

The optimization of a synthetic process for the preparation of HMFS handle, which is used for the solid-phase synthesis of peptides and oligonucleotides, is presented.

ACKNOWLEDGMENTS

This work was partially supported by the DGICYT (PB97-0941-C02-01 and PB96-1490) and the Generalitat de Catalunya [Grups Consolidats (1999SGR 00042 and 1998SGR-1) and Centre de Referència en Biotecnologia].

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AN IMPROVED SYNTHESIS OF N-[(9-HYDROXYMETHYL)-2-FLUORENYL]SUCCINAMIC ACID (HMFS), A VERSATILE HANDLE FOR THE SOLID-PHASE SYNTHESIS OF BIOMOLECULES

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AN IMPROVED SYNTHESIS OF N-[(9-HYDROXYMETHYL)-2-FLUORENYL]SUCCINAMIC ACID (HMFS), A VERSATILE HANDLE FOR THE SOLID-PHASE SYNTHESIS OF BIOMOLECULES

Abstract

ACKNOWLEDGMENTS

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