A RAPID, SELECTIVE, AND EFFICIENT METHOD FOR DEPROTECTION OF SILYL ETHERS CATALYZED BY BISMUTH(III) SALTS

Abstract

A variety of trimethylsilyl (TMS) ethers of alcohols and phenols are easily and rapidly removed in the presence of catalytic amounts of bismuth(III) salts, including BiCl₃, Bi(TFA)₃, and Bi(OTf)₃ in methanol at room temperature in excellent yields. tert-Butyldimethylsilyl (TBDMS) ethers are inert towards BiCl₃ and Bi(TFA)₃, but in the presence of Bi(OTf)₃, the corresponding alcohols are obtained in excellent yields.

ACKNOWLEDGMENTS

We are thankful to the Isfahan University Research Council for partial support of this work.