FACILE SYNTHESIS OF SATURATED EIGHT-MEMBERED RING LACTONES

Abstract

The synthesis of functionalized saturated eight-membered ring lactones from their corresponding seco acids is a very facile process using conventional macrolactonization protocols. This heretofore unrecognized and overlooked strategy is illustrated for several examples. A possible explanation for the success of this approach is also presented.

ACKNOWLEDGMENT

This work was generously supported by the American Cancer Society and the NSF-EPSCoR program. Acknowledgment is also made to the Donors of the Petroleum research Fund, administered by the American Chemical Society, for additional support of this research.