CONVENIENT SYNTHESIS OF RETINOL-RELATED POLYENES THROUGH HYDROXYALKYLATION OF 3-SULFOLENES

Abstract

Convenient synthesis of retinol-related polyenes is described through hydroxyalkylation of 3-sulfolenes followed by one-pot desulfonylation and dehydration in the presence of POCl₃/pyridine in toluene.

Keywords:

• Polyenes
• Sulfolene
• Alkylation
• Desulfonylation
• Dehydration

ACKNOWLEDGMENTS

We (TS and SVB) thank Department of Science and Technology, New Delhi, India and (TS and TSC) thank the National Science Council of the Republic of China for financial support. We are grateful to RSIC and TIFR, Mumbai for spectral data.