![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
A convenient method for the synthesis of a series of 4-trichloromethyl-pyrimidin-2-ylamines from the reaction of 4-trichloromethyl-2-chloropyrimidine and ammonium hydroxide, primary- and secondary-amines, and guanidine hydrochloride, is reported. This reactions was also extended to obtain 4-trichloromethyl-2-alkoxy-pyrimidines.
ACKNOWLEDGMENTS
The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), PADCT-II/FINEP, PADCT-III/CNPQ 62.0228/97-0 – QEQ, and FAPERGS for financial support and fellowships from CAPES (I.L.P.) and FAPERGS (D.F.), are also acknowledged.