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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 31, 2001 - Issue 19
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Original Articles

A SIMPLE METHOD FOR THE SYNTHESIS OF 2-AMINO-1-(4′-METHOXYPHENYL)-PROPANE

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Pages 3005-3010 | Received 29 Sep 2000, Published online: 16 Aug 2006
 

Abstract

Synthesis of 2-amino-1-(4′-methoxyphenyl)-propane (II) starting from p-anisaldehyde (1) in 67% overall yield is described. Key reactions involved Horner–Wadswoth–Emmons olefination of 1 to form the ester 2 and Hoffmann degradation of amide 5 to obtain the amine II.

ACKNOWLEDGMENTS

KSR thanks Director, IICT for funding this project.

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