REACTION OF ISATOIC ANHYDRIDE WITH BIFUNCTIONAL REAGENTS: SYNTHESIS OF SOME NEW QUINAZOLONE FUSED HETEROCYCLES, 2-SUBSTITUTED ANILINOHETEROCYCLIC DERIVATIVES AND OTHER RELATED COMPOUNDS

A. A. Fadda Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt

Hala M. Refat Department of Chemistry, Faculty of Education, Suez Canal University, Al-Arish, Egypt

M. E. A. Zaki National Research Centre, Dokki, Cairo, Egypt

Eman Monir Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt

Abstract

A new synthesis of quinazolone fused heterocycles (2, 5, 8), anilinoheterocycles (4, 7, 10, 12, 14) and substituted 2-aminoquinoline (15, 16) based on the reaction of isatoic anhydride (1) with different active bifunctional compounds in presence of glacial acetic acid and freshly fused sodium acetate is described. Structures of the newly prepared compounds are established by chemical and spectral data.

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REACTION OF ISATOIC ANHYDRIDE WITH BIFUNCTIONAL REAGENTS: SYNTHESIS OF SOME NEW QUINAZOLONE FUSED HETEROCYCLES, 2-SUBSTITUTED ANILINOHETEROCYCLIC DERIVATIVES AND OTHER RELATED COMPOUNDS

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REACTION OF ISATOIC ANHYDRIDE WITH BIFUNCTIONAL REAGENTS: SYNTHESIS OF SOME NEW QUINAZOLONE FUSED HETEROCYCLES, 2-SUBSTITUTED ANILINOHETEROCYCLIC DERIVATIVES AND OTHER RELATED COMPOUNDS

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