N-3-ALKYLATION OF URACIL AND DERIVATIVES VIA N-1-BOC PROTECTION

Saul Jaime-Figueroa Roche Bioscience, 3401 Hillview Ave., Palo Alto, CA, 94304, U.S.A.Correspondence[email protected]

Alejandro Zamilpa Roche Bioscience, 3401 Hillview Ave., Palo Alto, CA, 94304, U.S.A.

Angel Guzmán Roche Bioscience, 3401 Hillview Ave., Palo Alto, CA, 94304, U.S.A.

David J. Morgans Jr. Roche Bioscience, 3401 Hillview Ave., Palo Alto, CA, 94304, U.S.A.

Abstract

An easy and efficient synthesis of 3-alkyluracils is described. Thus, BOC-protection at N-1 of uracil permits selective alkylation at N-3. This protecting group can be removed under very mild conditions.

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N-3-ALKYLATION OF URACIL AND DERIVATIVES VIA N-1-BOC PROTECTION

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N-3-ALKYLATION OF URACIL AND DERIVATIVES VIA N-1-BOC PROTECTION

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