A CONVENIENT SYNTHESIS OF 4-SUBSTITUTED-4′-(2-THIENYL)- 2,2′-BITHIAZOLES AS POTENTIAL PHOTOTOXIC AGENTS

Shiv P. Singh Chemistry Department, Kurukshetra University, Kurukshetra, 136 119, India

Rajesh Naithani Chemistry Department, Kurukshetra University, Kurukshetra, 136 119, India

Ranjana Aggarwal Chemistry Department, Kurukshetra University, Kurukshetra, 136 119, India

Om Prakash Chemistry Department, Kurukshetra University, Kurukshetra, 136 119, India

Abstract

Alpha-tosyloxyacetylthiophene (3), obtained by the hypervalent iodine oxidation of 2-acetylthiophene (2) using [hydroxy- (tosyloxy)iodo]benzene (HTIB), on treatment with rubeanic acid exclusively generates 4-(2-thienyl)thiazole-2-thiocarboxamide (4) which upon subsequent treatment with a variety of alpha-tosyloxyketones (5) affords the title compounds (6) in excellent yields.

ACKNOWLEDGMENTS

We are grateful to the University Grants Commission, New Delhi for financial assistance.

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A CONVENIENT SYNTHESIS OF 4-SUBSTITUTED-4′-(2-THIENYL)- 2,2′-BITHIAZOLES AS POTENTIAL PHOTOTOXIC AGENTS

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A CONVENIENT SYNTHESIS OF 4-SUBSTITUTED-4′-(2-THIENYL)- 2,2′-BITHIAZOLES AS POTENTIAL PHOTOTOXIC AGENTS

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