Microwave-Assisted Solvent-Free Synthesis of trans-Cinnamic Acids Using Lithium Chloride as Catalyst

Abstract

A simple and efficient procedure has been developed for the synthesis of trans-cinnamic acids 3 by the condensation of aromatic aldehydes 1 with malonic acid 2 using LiCl as catalyst under solvent-free conditions using microwave irradiation. The products are obtained in excellent yields and in a state of high purity.

Keywords:

• trans-Cinnamic acids
• Lithium chloride
• Microwave-assisted synthesis
• Solvent-free

Acknowledgment

The authors are grateful to the Director, Indian Institute of Chemical Technology, Hyderabad, India for providing ¹H NMR spectra.