A Convenient Synthesis of Novel N′-tert-Butyl-N′-Substituted Benzoyl-N-(Substituted Phenyl)aminocarbonylhydrazines and Their Derivatives

Abstract

N-tert-butyl-N-substituted benzoylhydrazines were prepared in two convenient procedures with good yields, subsequent reaction with substituted phenylisocyanates in 1,2-dichloroethane provided a series of novel N′-tert-butyl-N′-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines. Further treatment with oxalyl chloride gave their derivatives in good yields. The title compounds exhibit moderate larvicidal activities and anticancer activities.

Keywords:

• N′-tert-Butyl-N′-substituted benzoylhydrazine
• Phenylisocyanate
• Benzoylphenylurea
• Insect growth regulators

Acknowledgments

We gratefully acknowledge support of this work by the National Natural Science Foundation of China (20202005) and the Research Fund for the Doctoral Program of Higher Education (20010055006) and the Foundation for the author of National Excellent Doctoral Dissertation of P.R. China (200255).