Multistep Microwave-Assisted Solvent-Free Organic Reactions: Synthesis of 4-Oxo-tetrahydro-pyridine

Abstract

Preparation and ring-closure of 2-dimethylaminomethylene-5-substituted-3-oxo-pent-4-enoic acid benzyl esters to dihydropyridine rings are efficiently and quickly carried out under solvent-free conditions in an open-vessel microwave system. The syntheses of 1,6-disubstituted-4-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid benzyl esters are reported.

Keywords:

• Microwave irradiation
• 4-Oxo-tetrahydro-pyridine
• Solvent-free
• Chirality
• Stereoselective synthesis

Acknowledgments

This work was partially supported by “Progetto Strategico sulle applicazioni delle Microonde, CNR, Rome.”

Notes

^aWork is in progress to delucidate this surprising high stereoinduction. The results will be reported in due course.