Synthesis of New 4,5‐Dihydro‐3(2H)‐pyridazinone Derivatives

Abstract

A novel series of compounds structurally related to nonpeptide angiotensin II (AII) receptor antagonists derived from 4,5‐dihydro‐3(2H)‐pyridazinones has been prepared. In these compounds, the spacer is linked to the C4 of the heterocyclic ring.

Keywords:

• Pyridazinone
• Angiotensin II
• Renin‐angiotensin system
• Blood pressure

Acknowledgments

The authors are indebted to PRONEX (Brazil) and CNPq for financial support of this work.