A Convenient Synthesis of Octahydro‐pyrazino[1,2‐a]pyrazine

Abstract

Octahydro‐pyrazino[1,2‐a]pyrazine has been prepared by a new and efficient method starting from 1,3‐dichloro‐2‐propanol and N‐tosylated diethylenetriamine. The structure of title compound was determined by spectroscopy and x‐ray diffraction technique.

Keywords:

• Piperazine
• Pyrazine
• Macrocycle
• Condensation
• Cyclization

Acknowledgments

This research was supported by the National Science Foundation of China (No. 29972034).

Notes

^aX‐ray crystallograph for 5: C₇H₂₀Br₃N₃O, Mr = 401.99, crystal, 0.30 × 0.20 × 0.10 mm, monoclinic, Space group P2(1)/c, T = 293(2) K, a = 10.238(2) Å, b = 9.5959(19) Å, c = 14.020(3) Å, β = 91.04(3) Å, v = 1377.2(5) Å³, Z = 4, λ(MoK_α) = 0.71073 Å, Dc = 1.924 Mg/m³, µ = 8.767 mm⁻¹, F(000) = 784, 9573 intensities, collected 2.57° < θ < 27.48°, R1 (I > 2σ(I)) = 0.0457, wR2 = 0.0829, s = 0.849, largest diff. Peak and hole: 0.963 and −0.975 e Å⁻³. Atomic coordinates, bond angles, bond lengths and thermal parameters assisted to this compound have been deposited at the Cambridge Crystallographic Data Centre in CIF file. CCDC number: 200701.