A Practical Two‐Step Synthesis of 3‐Alkyl‐2,3‐dihydro‐1H‐isoindolin‐1‐ones

Yuan‐Ping Ruan Department of Chemistry, Xiamen University, Xiamen, Fujian, 361005, China

Ming‐De Chen Department of Chemistry, Xiamen University, Xiamen, Fujian, 361005, China

Ming‐Zhu He Department of Chemistry, Xiamen University, Xiamen, Fujian, 361005, China

Xiang Zhou Department of Chemistry, Xiamen University, Xiamen, Fujian, 361005, China

Pei‐Qiang Huang Department of Chemistry, Xiamen University, Xiamen, Fujian, 361005, ChinaCorrespondence[email protected]

Abstract

A flexible approach to 3‐alkyl‐2,3‐dihydro‐1H‐isoindolin‐1‐ones via the reductive‐alkylation procedure is described. Present method is versatile in scope, allowing the easy introduction of various C‐3 carbon‐substituents by Grignard addition to phthalimide.

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Acknowledgment

We are grateful to the NNSC for financial support.

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A Practical Two‐Step Synthesis of 3‐Alkyl‐2,3‐dihydro‐1H‐isoindolin‐1‐ones

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A Practical Two‐Step Synthesis of 3‐Alkyl‐2,3‐dihydro‐1H‐isoindolin‐1‐ones

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