A Convenient and Effective Method for Synthesizing β‐Amino‐α,β‐Unsaturated Esters and Ketones

Abstract

A convenient and effective method for the preparation of β‐amino‐α,β‐unsaturated esters and ketones has been developed through silica gel‐catalyzed and solvent‐free reactions of β‐dicarbonylic compounds with ammonia and primary amines.

Keywords:

• Amination
• β‐Diketone
• β‐Keto ester
• β‐Amino‐α,β‐unsaturated ketone
• β‐amino‐α,β‐unsaturated ester
• Silica gel

Acknowledgments

The project was supported by NSFC (No. 20272002), the Excellent Young Teachers Program and the Scientific Research Foundation for the Returned Oversea Chinese Scholars of Ministry of Education of China, and Peking University (President grant).