A Convenient Synthesis of Novel 1‐[2‐(Benzimidazol‐2‐yl)ethoxy]‐2,6‐diarylpiperidin‐4‐ones

Abstract

Upon the study of biological evaluation of benzazolylethoxypiperidones, an array of novel benzimidazolylethoxypiperidones were synthesized. 2,6‐Diarylpiperidin‐4‐ones upon strategical N‐hydroxylation, cyanoethylation followed by acid aided condensation with o‐phenylenediamine afforded a convenient route to novel 1‐[2‐(benzimidazol‐2‐yl)ethoxy]‐2,6‐diarylpiperidin‐4‐ones.

Keywords:

• Cyanoethylation
• Piperidine derivatives
• Benzimidazole moiety, Synthetic compounds

Acknowledgment

The authors are grateful to Prof. K. Pandiarajan, Head, Department of Chemistry, Annamalai University for providing needed facilities. One of the authors, S.K., is grateful to University Grants Commission, New Delhi for financial support. SB wishes to thank Council of Scientific & Industrial Research, New Delhi for the award of Senior Research Fellowship.