Microwave Assisted Synthesis of Fluorinated Hexahydro 1,3,5‐Triazine Derivatives in Aqueous Medium and One Pot Synthesis of 1,2,4‐Triazolo(4,3‐a)1,3,5‐triazines

Abstract

A multi‐component condensation of substituted phenylthiourea/urea, aqueous formaldehyde and substituted aromatic/heterocyclic amines lead to 2‐thioxohexahydro‐1,3,5‐triazines (4) in aqueous medium under microwave irradiation in 30–60 sec in quantitative yield with reasonable purity. Further, triazolo[4,3‐a]triazines were also prepared by a one‐pot reaction of ‘in situ’ synthesized triazinyl hydrazine (7) with CS₂ (9).

Keywords:

• Fluorinated hexahydro 1,3,5‐triazine
• Microwave irradiation
• 1,2,4‐Triazolo(4,3‐a) 1,3,5‐triazine

Acknowledgement

Financial assistance from U.G.C. (New Delhi) is gratefully acknowledged. We are also thankful to RSIC, CDRI, Lucknow, for the elemental and spectral analyses.