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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 7
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Original Articles

Lithium Perchlorate Mediated Three‐Component Preparation of α‐Aminonitriles Under Solvent‐Free Conditions

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Pages 1207-1214 | Received 01 Jun 2003, Published online: 21 Aug 2006
 

Abstract

A three‐component reaction between aliphatic or aromatic aldehyde, an amine and trimethylsilyl cyanide mediated by solid LiClO4, gave amino nitriles in good to excellent yields. The reaction proceeded smoothly under solvent‐free conditions without any side products.

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