Microscale Preparation of Isotopically Enriched ³⁷ClHC˭CHF

Abstract

Chlorination of 1‐bromo‐2‐fluoroethylene followed by reductive dehalogenation of the produced 1‐bromo‐1,2‐dichloro‐2‐fluoroethane selectively affords 1‐chloro‐2‐fluoroethylene. This process is suitable to produce ³⁷Cl isotopically enriched ClHC˭CHF on a convenient scale (3.8 mmol).

Keywords:

• Fluoroalkenes
• Isotopic labeling
• ClHC˭CHF
• Reductive dehalogenation

Acknowledgment

The author thanks Daniela Baldan for helpful aid in article preparation.