Synthesis of Methoxy‐2‐hydroxy‐1,4‐naphthoquinones and Reaction of One Isomer with Aldehydes Under Basic Conditions

Abstract

Two protocols for the synthesis of methoxy‐2‐hydroxy‐1,4‐naphthoquinones were investigated in order to evaluate their behavior towards aldehydes under amine‐basic conditions. Both the nature of the quinone and aliphatic aldehyde contribute to the viability of this condensation as well as further transformations.

Keywords:

• Methoxy‐2‐hydroxy‐1,4‐naphthoquinones
• Methoxy‐naphtho[2,3‐b]pyran‐5,10‐diones
• Aldehydes
• Isomer

Acknowledgments

The authors thank the University of the Western Cape and the National Research Foundation for financial support.