Effective Synthesis of 7‐Amino‐6‐cyano‐5‐aryl‐5H‐pyrano[2,3‐d]pyrimidine‐2,4(1H,3H)‐diones Under Microwave Irradiation

Abstract

A series of 7‐amino‐6‐cyano‐5‐aryl‐5H‐pyrano[2,3‐d]pyrimidine‐2,4(1H,3H)‐diones were synthesized by the reaction of arylidenemalononitrile with barbituric acid under microwave irradiation without catalyst with shorter reaction time and higher yields.

Keywords:

• Microwave irradiation
• Barbituric acid
• Dione
• Heterocyclic compounds

Acknowledgments

We thank the Nature Science Foundation of the Jiangsu Province (No. BK2001142) and the Nature Science Foundation of Jiangsu Education Department (No. 01KJB150008) and the Key Laboratory of Chemical Engineering and Technology of the Jiangsu Province Open Foundation (No. KJS02060) and the Nature Science Foundation of the Guangdong Province (No. 31792) for financial support.