One‐Pot Synthesis of 4‐Alkoxybenzo[c]thiophenes

Abstract

The reaction of N‐bromosuccinimide with 4,5,6,7‐tetrahydrobenzo[c]thiophen‐4‐ones in the presence of 2,2′‐azo‐bis‐isobutyronitrile followed by heating under reflux with different alcohols produces 4‐alkoxybenzo[c]thiophenes in good yield.

Keywords:

• One‐pot synthesis
• 4‐Alkoxybenzo[c]thiophenes
• N‐bromosuccinimide
• α,β‐Unsaturated cyclic ketone

Acknowledgment

This work was partially supported by a grant from the Research Council of Tehran University of Medical Sciences.