Facile Preparation of α‐Acyloxyacetaldehyde, a Versatile Intermediate in the Synthesis of Antiviral Nucleosides

Abstract

This report describes a novel and simple method for the preparation of a versatile intermediate, α‐acyloxyacetaldehyde and its acetals, and its application to the synthesis of 4‐acetoxy‐2‐acyloxymethyl‐1,3‐oxathiolane, an important intermediate in the synthesis of biologically active nucleosides.

Keywords:

• Nucleosides
• Synthesis
• HIV‐1
• HBV