A Convenient Preparation of Tetrahydrofuran‐Based Diamines

Abstract

A convenient, three‐step preparation of tetrahydrofuran‐based diamines as combinatorial building blocks from 3,4‐epoxytetrahydrofuran is described.

^†Dedicated to the memory of Mom for her initiation and inspiration.

Keywords:

• Tetrahydrofuran
• Diamines
• Amino groups

Notes

^†Dedicated to the memory of Mom for her initiation and inspiration.

^a3,4‐Epoxytetrahydrofuran is available from Acros Organics now. This epoxide was also prepared in this laboratory by treatment of 2,5‐dihydrofuran with urea hydrogen peroxide addition compound and phthalic anhydride in ethyl acetate at room temperature.