Three‐Component Synthesis of 3‐Aminomethylene‐thiochroman‐2,4‐diones from 4‐Hydroxythiocoumarin

Abstract

A three‐component synthesis of 3‐aminomethylene‐thiochroman‐2,4‐dione derivatives 2–22 by the condensation reactions of amines, α‐aminoacids, ureas, and carbamates with 4‐hydroxythiocoumarin 1, respectively, in the presence of triethyl orthofomate is described.

Keywords:

• Three‐component condensation
• 3‐Methylene‐thiochroman‐2,4‐dione
• 4‐Hydroxythiocoumarin
• Amine
• Triethyl orthofomate

Acknowledgments

We would like to thank Korea Research Council for Industrial Science and Technology (KK‐0301‐N0) for financial support.