Abstract
An efficient synthesis of p‐nitrophenyl‐(9‐fluorenylmethoxy carbonylamino) methyl carbamates using isocyanates derived from Fmoc‐amino acid azides and p‐nitrophenol in presence of an equimolar quantity of N‐ethyldiisopropyl amine is described. All the carbamates have been isolated as crystalline solids and are fully characterized. Further, their utility for the synthesis of dipeptidyl ureas has been demonstrated.
Acknowledgments
We are grateful to Department of Science and Technology, Govt. of India for financial assistance. We thank Sophisticated Instruments Facility, I. I. Sc., for NMR data and Hikal India Ltd., Bangalore for optical rotation measurements.