A Short Enantioselective Synthesis of (R)‐(+)‐γ‐Jasmolactone

Abstract

(R)‐(+)‐γ‐Jasmolactone (1b) was synthesized in 92% ee in two steps, starting from the easily prepared (S)‐(−)‐3‐(5‐oxo‐tetrahydro‐furan‐2‐yl)‐propionic acid benzyl ester (2). The key step features an inversion of configuration of the stereogenic center.

Keywords:

• γ‐Jasmolactone
• Enantioselective synthesis
• Stereogenic center
• Column chromatography

Acknowledgments

G. C. Clososki and L. J. Missio thank FAPESP for fellowships. J. V. Comasseto thanks FAPESP, CNPq, and CAPES for support.