Efficient Synthesis of Polyethylene Glycol Mono‐Carboxylate via Michael Conjugate Addition

Abstract

Poly(ethylene glycol) (PEG) with one carboxylate group, the very useful precursors for the synthesis of the PEG derived heterobifunctional linkers, are synthesized in high yield in one‐pot via Michael conjugate addition of acrylate esters with PEG and catalyst amount of sodium in THF.

Keywords:

• Mono-carboxylated PEG
• Heterobifunctional linker
• Michael conjugate addition
• Mono‐carboxylate terminal

Notes

^aA number of companies are providing heterobifunctional linkers: such as Pierce Inc. Sigma–Aldrich, Solulink Inc.