Synthesis of the Four 3‐Aminotricyclo [2.2.1.0(2,6)] Heptane‐1,3‐Dicarboxylic Acid Isomers

Reinhardt B. Baudy Chemical and Screening Sciences, Wyeth Research Inc., Princeton, New Jersey, 08543‐8000, USACorrespondence[email protected]

Jean Y. Sze Chemical and Screening Sciences, Wyeth Research Inc., Princeton, New Jersey, 08543‐8000, USA

John A. Butera Chemical and Screening Sciences, Wyeth Research Inc., Princeton, New Jersey, 08543‐8000, USA

Abstract

A process to prepare the four stereoisomers of the tricyclic 3‐aminotricyclo[2.2.1.0(2,6)] heptane‐1,3‐dicarboxylic acid, a potent selective inhibitor of the EAAT2 transporter, is described.

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Synthesis of the Four 3‐Aminotricyclo [2.2.1.0(2,6)] Heptane‐1,3‐Dicarboxylic Acid Isomers

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Synthesis of the Four 3‐Aminotricyclo [2.2.1.0(2,6)] Heptane‐1,3‐Dicarboxylic Acid Isomers

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