Abstract
Placebo effects are well-known phenomena in medicine and biology. In fact, placebos are used as control conditions in randomized cross-over clinical trials to validate new treatments. Only recently, however, has it become apparent that the conditioning and/or expectation effects provided by the experience of placebos can influence the results of clinical trials. It seems that combining shams and sequences has prejudiced the conclusions provided by cross-over designs. Frighteningly, this bias is always in the same direction, namely to increase the risk of rejecting potentially valid treatments. New models for clinical trials should be encouraged if we wish to market new and truly valid treatments.
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Declaration of funding
The authors declare no conflict of interest and have received no payment in preparation of this manuscript
Declaration of financial/other relationships
G.L., S.L., and, P.G. have disclosed that they have no significant relationships with or financial interests in any commercial companies related to this study or article.
The peer reviewers on this manuscript have disclosed that they have no relevant financial relationships.