The relationship between vitamin D and obesity

Abstract

Currently, vitamin D deficiency and obesity are pandemic diseases and they are associated with cardiovascular (CV) disease, metabolic syndrome and type 2 diabetes mellitus (T2DM) and other diseases. Concentrations of 25-hydroxyvitamin D (25(OH)D) (25D) are considered as the best indicator of total body vitamin D stores. An association between reduced circulating 25D concentrations and obesity is well known, but the mechanisms are not totally clear. The role of vitamin D supplementation is still uncertain and prospective interventions will establish its influence, if any, in the treatment of obesity. Vitamin D deficiency is associated with the presence of a cardiometabolic risk profile in the obese. Future trials may establish a role for Vitamin D supplementation in individuals at increased CV risk.

Keywords::

• Cardiovascular disease
• Metabolic syndrome
• Obesity
• Type 2 diabetes
• Vitamin D

Transparency

Declaration of funding

This work was supported by grant No. 173033 (to E.R.I.) from the Ministry of Education, Science and Technological Development of the Republic of Serbia.

Declaration of financial/other relationships

S.S., E.S., and E.R.I. have disclosed that they have no significant relationships with or financial interests in any commercial companies related to this study or article.