Association between glycemic indices and beta cell function in patients with newly diagnosed type 2 diabetes

Abstract

Objective:

To identify the relationship between glycemic indices and β cell function in patients with newly diagnosed type 2 diabetes.

Methods:

The cross-sectional analysis included 61 patients with newly diagnosed type 2 diabetes who received continuous glucose monitoring (CGM) for 72 hours. The association between β cell function and glycemic indices including A1C and glycemic variability was investigated.

Results:

A1C (r = −0.405, p = 0.001) and standard deviation of blood glucose (SDBG, r = −0.274, p = 0.032) were significantly correlated to HOMA-β cell function (HBCI), whereas mean amplitude of glycemic excursions (MAGE, r = −0.210, p = 0.104) was not informative. After multiple confounders adjustments, A1C (β = −7.35, p < 0.001), MAGE (β = −4.64, p = 0.040), and SDBG (β = −12.3, p = 0.012) were associated with HBCI.

Conclusion:

A1C and glycemic variability were both associated with β cell function in patients with newly diagnosed type 2 diabetes. The main limitations of the present study are the cross-sectional design in nature and the limited sample size.

Key words::

• Glycated hemoglobin
• Glycemic variability
• Type 2 diabetes

Transparency

Declaration of funding

This study was not funded.

Declaration of financial/other relationships

F.S.F., X.L.C., Y.P.G., L.C.W., L.L., J.L., H.T., and C.L.L. have disclosed that they have no significant relationships with or financial interests in any commercial companies related to this study or article.

CMRO peer reviewers on this manuscript have no relevant financial or other relationships to disclose.