Impact of postsurgical opioid use and ileus on economic outcomes in gastrointestinal surgeries

Abstract

Objectives:

To assess the incidence and economic impact of postoperative ileus (POI) following laparotomy (open) and laparoscopic procedures for colectomies and cholecystectomies in patients receiving postoperative pain management with opioids.

Methods:

Using the Premier research database, we retrospectively identified adult inpatients discharged between 2008 and 2010 receiving postsurgical opioids following laparotomy and laparoscopic colectomy and cholecystectomy. POI was identified through ICD-9 diagnosis codes and postsurgical morphine equivalent dose (MED) determined.

Results:

A total of 138,068 patients met criteria, and 10.3% had an ileus. Ileus occurred more frequently in colectomy than cholecystectomy and more often when performed by laparotomy. Ileus patients receiving opioids had an increased length of stay (LOS) ranging from 4.8 to 5.7 days, total cost from $9945 to $13,055 and 30 day all-cause readmission rate of 2.3 to 5.3% higher compared to patients without ileus. Patients with ileus received significantly greater MED than those without (median: 285 vs. 95 mg, p < 0.0001) and were twice as likely to have POI. MED above the median in ileus patients was associated with an increase in LOS (3.8 to 7.1 days), total cost ($8458 to $19,562), and readmission in laparoscopic surgeries (4.8 to 5.2%). Readmission rates were similar in ileus patients undergoing open procedures regardless of MED.

Conclusions:

Use of opioids in patients who develop ileus following abdominal surgeries is associated with prolonged hospitalization, greater costs, and increased readmissions. Furthermore, higher doses of opioids are associated with higher incidence of POI. Limitations are related to the retrospective design and the use of administrative data (including reliance on ICD-9 coding). Yet POI may not be coded and therefore underestimated in our study. Assessment of pre-existing disease and preoperative pain management was not assessed. Despite these limitations, strategies to reduce opioid consumption may improve healthcare outcomes and reduce the associated economic impact.

Keywords: :

• Cholecystectomy – Colectomy – Healthcare and economic outcomes – Ileus – Morphine equivalent dose – Opioid – Postoperative pain

Transparency

Declaration of funding

This study was funded by Pacira. The potential publication of the results was not dependent upon approval or censorship from the sponsor.

Declaration of financial/other relationships

S.B.R. has disclosed that he is an employee of Premier Research Services, which received funding from Pacira Pharmaceuticals Inc. to conduct this analysis. T.J.G. and G.M.O. have disclosed that they received funding from Pacira Pharmaceuticals Inc. to conduct this analysis. J.P. and S.R. have disclosed that they have no significant relationships with or financial interests in any commercial companies related to this study or article. R.S. has disclosed that he is an employee of Pacira Pharmaceuticals Inc.

CMRO peer reviewers on this manuscript have no relevant financial or other relationships to disclose.