Action of cyclandelate on the development of collateral vessels in the rabbit

Summary

The development of collateral vessels after ligation of the external iliac artery and the femoral artery was studied in the rabbit. ‘Plastoid’ casts of the vascular system showed that daily oral administration of cyclandelate in doses of 100 or 250 mg./kg. accelerated the normal physiological development of the collateral vessels in a region with vascular insufficiency.

It is postulated that promotion of collateral vessel formation is one of the major actions of cyclandelate in peripheral vascular insufficiency when this condition is not based on vascular spasm. Where spasms are involved, the spasmolytic activity of cyclandelate plays a role in its therapeutic effect.

Key words::

• Cyclandelate
• collateral circulation