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Summary
In a multi-centre study conducted by 158 doctors in all regions of Spain, 782 patients with various urinary infections were treated orally using indanyl carbenicillin as the sole antibiotic agent. The majority (94%) were adult out-patients; 57% were women and 43 % men. Diagnoses included cystitis, pyelitis, cystopyelitis, pyelonephritis, urethritis, prostatitis, and lithiasis with concomitant infection. There were also some cases of non-specific asymptomatic bacteriuria, acute, chronic or recurrent in character.
Of 389 bacterial strains isolated from 318 cultures, the predominant organisms were E. coli (45%), Proteus (17.4%). and Pseudomonas (6%). Overall response to treatment was good in 85%, of patients (89%, in acute and 80%, in chronic cases).
In general, tolerance to indanyl carbenicillin was good and the side-effects seen in 9.9%, of cases were limited mainly to the gastro-intestinal tract. In only 8 of the 782 patients did the side-effects necessitate interruption of treatment. The incidence of allergic reactions was remarkably low.
The good results obtained during this multi-centre study confirm that indanyl carbenicillin is a well-tolerated and effective antibiotic for the oral treatment of urinary tract infections caused by a wide spectrum of micro-organisms.
Notes
* Paper originally presented at the International Indanyl Carbenicillin Symposium, Lanzarote. Canary Islands, Spain, March 1974.