The use of flavoxate in cystitis and renal colic

Summary

Two double-blind trials and one open study were carried out to assess the efficacy of the spasmolytic, flavoxate, in relieving the pain and discomfort associated with various urological conditions. In the first two studies, 24 patients with renal colic and 34 with cystitis or urethrotrigonitis were treated orally with either 0.2 g. flavoxate t.d.s. or placebo. In the open study, 25 patients with acute renal colic were given a single i/v injection of flavoxate (0–1 g.).

Thirty-four (68 %) of the 54 patients receiving flavoxate showed a good or moderate response in terms of symptom relief compared with only 8 (28%) of the patients on placebo. The results of cystometrography in 7 patients on flavoxate and 7 on placebo showed that the increase in bladder capacity and the reduction in pressure after flavoxate treatment were statistically significant but not so in the case of placebo. No side-effects or adverse reactions were noted in any of the patients treated.

Key words: :

• Flavoxate
• parasympatholytics
• colic
• renal
• cystitis