Prazosin og hydralazin: Ækvipotente antihypertensive doser i kombinations - behandling med propranolol

Summary

In a crossover study between hydrallazine and prazosin in 15 patients, also treated with the β-receptor blocking agent propranolol, 1 mg prazosin was found to be equipotent to 30 mg hydrallazine. All patients were known to tolerate hydrallazine. Side-effects during prazosin treatment were carefully monitored: 9 patients had no side-effects at all, 4 patients had minor non-persistent initial side-effects. In 1 patient prazosin was discontinued because of severe headache. One patient fainted on the second day of prazosin treatment, probably from a micturition syncope. He continued treatment without side-effects. The side-effects might have been avoided by using a smaller starting dose of prazosin, maybe 0.5 mg t.i.d. It is concluded that prazosin may be used as an alternative to hydrallazine, but it is still not known whether this is the final position of prazosin among different antihypertensive drugs.